ISSN

2231-3915 (Online)
2231-3907 (Print)


Author(s): Rajesh Y. Chaudhari, Sachin S. Rane, Mahesh S. Nemade

Email(s): rychaudhari@gmail.com

DOI: 10.52711/2231-3915.2022.00005   

Address: Rajesh Y. Chaudhari*, Sachin S. Rane, Mahesh S. Nemade
Department of Pharmaceutical Chemistry, TVES’s Honorable Lokasevak Madhukarrao Chaudhari College of Pharmacy, Faizpur, Tal- Yawal, Dist- Jalgaon-425503 Maharashtra.
*Corresponding Author

Published In:   Volume - 12,      Issue - 2,     Year - 2022


ABSTRACT:
A novel, simple, accurate and rapid Reverse Phase High Performance Liquid Chromatography (RP-HPLC) method has been developed and validated for the determination of Nebivolol and Valsartan in bulk and tablet dosage form. Gradient elution chromatography has been developed on C18 column (5µm, 4.6mm* 250mm) with a mobile phase consist of pH 4 acetonitrile,water and Methanol (25:35:40) with a flow rate of 1ml/min at detection of 270 nm wavelength. The retention time for Nebivolol and Valsartan was found to be 4.59 and 10.2 respectively. Chromatography parameters were validated as per ICH guidelines and the method can be applicable for routine quantitative analysis of drugs in combined dosage form.


Cite this article:
Rajesh Y. Chaudhari, Sachin S. Rane, Mahesh S. Nemade. A Validated RP-HPLC Method Development and Validation for The Simultaneous Estimation of Nebivolol and Valsartan in Bulk Drug and Pharmaceutical Dosage Form. International Journal of Technology. 2022; 12(2):25-1. doi: 10.52711/2231-3915.2022.00005

Cite(Electronic):
Rajesh Y. Chaudhari, Sachin S. Rane, Mahesh S. Nemade. A Validated RP-HPLC Method Development and Validation for The Simultaneous Estimation of Nebivolol and Valsartan in Bulk Drug and Pharmaceutical Dosage Form. International Journal of Technology. 2022; 12(2):25-1. doi: 10.52711/2231-3915.2022.00005   Available on: https://ijtonline.com/AbstractView.aspx?PID=2022-12-2-2


REFERENCES:
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2.    http://journals.lww.com/cardiovascularpharm/toc/1988/05000
3.    https://www.drugbank.ca/drugs/DB04861
4.    https://en.wikipedia.org/wiki/Nebivolol
5.    https://www.google.co.in/webhp?sourceid=chromeinstant&rlz=1C1MIMX_enIN517IN519&ion=1&espv=2&ie=UTF-8#q=drug+bank+of+valsartan
6.    https://www.drugbank.ca/drugs/DB00177
7.    https://en.wikipedia.org/wiki/Valsartan
8.    https://www.google.co.in/webhp?sourceid=chromeinstant&rlz=1C1MIMX_enIN517IN519&ion=1&esp=2&ie=UTF-8#q=combination+of+valsartan+and+nebivoal
9.    S. N. Meyyanathan, Arunadevi S. Birajdar and Bhojraj Suresh. Simultaneous Estimation of Nebivolol Hydrochloride and Valsartan and Nebivolol Hydrochloride andHydrochlorothiazide in Pharmaceutical Formulations by UV Spectrophotometric Methods. Indian J.Pharm. Educ. Res. 44(2), Apr-Jun.
10.    S. U. Kokil and M. S. Bhatia. Simultaneous Estimation of Nebivolol Hydrochloride and Valsartan using RP HPLC. Indian Journal of Pharmaceutical Sciences. 2009.
11.    K.R. Gupta, A.D. Mahapatra, A.R.Wadodkar and S.G.Wadodkar. Simultaneous UV Spectrophotometric Determination of Valsartan and Amlodipine in tablet. International Journal of Chem Tech Research. Jan-Mar. 2010
12.    Anandakumar K. And Jayamariappan M. Absorption Correction Method For The Simultaneous Estimation of Amlodipine Besylate, Valsartan and Hydrochlorothiazide in Bulk and in Combined Tablet Dosage. International Journal of Pharmacy and Pharmaceutical Sciences.. 23 Oct. 2010.

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