Author(s):
Suyash Ingle*, Nikhil Shrisunder, Saili Madur, Swati Kharav, Sakshi Survase, Om Kothari, Vivek Chavan, Shravani Kawale, Zeeshan Khan
Email(s):
suyashingle07@gmail.com , nikhilshrisunder1989@gmail.com , sailimadur253@gmail.com , suyashingle1806@gmail.com
DOI:
10.52711/2231-3915.2026.00005 
Address:
Suyash Ingle*, Nikhil Shrisunder, Saili Madur, Swati Kharav, Sakshi Survase, Om Kothari, Vivek Chavan, Shravani Kawale, Zeeshan Khan
Gandhi Natha Rangji College of Pharmacy, Solapur, Maharashtra, India.
*Corresponding Author
Published In:
Volume - 16,
Issue - 1,
Year - 2026
ABSTRACT:
Gas Chromatography (GC) is an essential analytical technique widely employed for the separation, identification, and quantification of volatile and semi-volatile compounds. It has become an indispensable tool in diverse fields, including pharmaceutical sciences, environmental monitoring, forensic analysis, food safety, and petrochemical industries. The technique operates on the principle of differential partitioning of analytes between a mobile gaseous phase and a stationary phase within a chromatographic column, enabling precise and high-resolution separations. Gas Chromatography with fundamental principles, instrumentation, operational parameters, and advancements with a focus on detectors such as Flame Ionization Detector (FID), Electron Capture Detector (ECD), and -Mass Spectrometry (GC-MS) having crucial role in analysis of different compounds. Along with the integration of capillary columns, temperature programming, and automation has significantly enhanced the sensitivity, accuracy, and efficiency of GC in modern analytical applications. Additionally, emerging trends such as miniaturized GC systems, multidimensional and hyphenated techniques have expanded its capabilities in complex sample analysis.
Cite this article:
Suyash Ingle, Nikhil Shrisunder, Saili Madur, Swati Kharav, Sakshi Survase, Om Kothari, Vivek Chavan, Shravani Kawale, Zeeshan Khan. International Journal of Technology. 2026; 16(1):43-2. doi: 10.52711/2231-3915.2026.00005
Cite(Electronic):
Suyash Ingle, Nikhil Shrisunder, Saili Madur, Swati Kharav, Sakshi Survase, Om Kothari, Vivek Chavan, Shravani Kawale, Zeeshan Khan. International Journal of Technology. 2026; 16(1):43-2. doi: 10.52711/2231-3915.2026.00005 Available on: https://ijtonline.com/AbstractView.aspx?PID=2026-16-1-5
REFERENCES:
1. Kitson, F.G., Larsen, B.S., and McEwen, C.N. (1996). Gas Chromatography and Mass Spectrometry: A Practical Guide. Academic Press.
2. McNair, H.M., Miller, J.M., and Snow, N.H. (2019). Basic Gas Chromatography. 3rd Edition, Wiley.
3. Snyder, L.R., Kirkland, J.J., and Dolan, J.W. (2011). Introduction to Modern Liquid Chromatography. Wiley.Sonia K, Nappinnai M. Development and validation of HPLC and UV-visible.
4. Zhang, Z., et al. Recent Advances in Gas Chromatography for Environmental Analysis. Trends in Analytical Chemistry. 2020; 123: 115768.
5. Smith, R.M. Before the Injection – Modern Methods of Sample Preparation for GC Analysis. Journal of Chromatography A. 2004; 1000(1-2): 3-27.
6. Lu, W., et al. Advancements in Two-Dimensional Gas Chromatography (GC×GC) for Complex Mixture Analysis. Analytical Chemistry. 2021; 93(4): 1573-1582.
7. Poole, C.F. Trends in Gas Chromatography: A 60-Year Perspective. Journal of Chromatography A. 2021; 1638: 461877.
8. International Journal of Analytical and Bioanalytical Chemistry, accepted 20 November 2015
9. Method Development: a Guide to Basics Quantitative C Qualitative HPLC, LC,GC Chromacademy.
10. Lalit V Sonawane Bioanalytical Method Validation and Its Pharmaceutical Application- A Review Pharmaceutica Analytica Acta 2014, 5:3 Center for Drug Evaluation and Research (CDER) Reviewer Guidance.
11. ICH Topic Q 2 (R1) Validation of Analytical Procedures: Text and Methodology
12. Instrumental Method of Chemical Analysis” by Chatwal Anand, Himalaya Publishing House, p.no.615-623.
13. Practical Pharmaceutical Chemistry, 4th edition, Part 2, by Beckett and Stenlake, CBS Publishers and Distributors, P.No.157-174.
14. Govt. of India, Ministry of Health and Family Welfare. Vol. 2. Delhi: Publication by Controller Of Publication; 2007. Indian Pharmacopoeia; pp. 484-554.
15. Gong ZY, et al. A ringdown breath acetone analyzer: performance and validation using gas chromatography- mass spectrometry. J Anal Bioanal Tech. 2014; S7: 013.
16. M. Sutar, S. Deshmukh, Significance of various chromatographic techniques in drug discovery and development, Int. J. Res. Pharm. 2013; 3(2): 282-289.
17. Hen Z, et al. Utilization of a matrix effect to enhance the sensitivity of residual solvents in static headspace gas chromatography. J Chromatogr Sep Tech. 2015; 6: 289.